癌症研究室

癌症是台灣十大死因之首,且發病率仍逐年增加。其中,雲嘉地區是國內口腔癌主要盛行處,我們的機構位處於雲嘉地區之教學醫院,故探討口腔癌之致病機轉及其預防或治療等相關研究,有其迫切的必要性。主要的研究導向是由研究部與放射腫瘤科合作建立,關注於口腔癌腫瘤調控機制及放射線治療之聯合應用。此外,我們也致力於各項癌症的研究,以期對癌症的起因、進程與治療能有更大的突破與發展。

1. 洪世凱主任:

現職

    大林慈濟醫院放射腫瘤科  科主任  2011/07迄今
    大林慈濟醫院腫瘤中心  主任  2016/06迄今
    花蓮慈濟大學醫學系  助理教授  2012/02迄今
    大林慈濟醫院放射腫瘤科  主治醫師  2005/02迄今

主要學歷

    陽明大學傳統醫藥研究所  博士  2008/09至2011/01
    陽明大學傳統醫藥研究所  碩士  2005/09至2008/06
    中國醫藥大學中醫系  醫學士  1993/09至2000/06

經歷

    馬偕紀念醫院放射腫瘤科  主治醫師  2004/07至2005/02
    馬偕紀念醫院放射腫瘤科  總醫師  2003/07至2004/06

 

2. 余芝嘉副研究員:

現職

    大林慈濟醫院研究部  副研究員  2025/03/01迄今

主要學歷

    國立中正大學分子生物研究所  博士  2010/09至2016/07
    國立嘉義大學生物科技研究所  碩士  2005/09至2007/06

經歷

    大林慈濟醫院研究部  助理研究員 2019/03~2025/02/28
    大林慈濟醫院研究部  專案助理研究員  2018/02~2019/03
    大林慈濟醫院研究部  專任研究助理  2008/07~2018/01

姓   名

計  畫  名  稱

計畫內擔任之工作

起迄年月

補助機構

洪世凱

Olaparib通過抑制 IL-17A調節口腔癌細胞的放射增敏、遷移和侵襲

主持人

2022/02~

2023/01

大林慈濟醫院

洪世凱

多面向發展智慧化放射治療

主持人

2022/01~

2022/12

佛教慈濟醫療財團法人
洪世凱

PARP抑制劑經由cGAS-STING訊號路徑誘導口腔癌細胞IRAK2增強放射敏感性

主持人

2021/02-2022/01

大林慈濟醫院
洪世凱

GLIPR1增強放射抗性口腔鱗狀細胞癌中的輻射誘導之侵襲和上皮-間質轉變

主持人

2020/02~

2021/01

大林慈濟醫院
洪世凱

創傷後成長與折損量表驗證研究

主持人

2019/08~

2020/07

大林慈濟醫院
洪世凱

IRAK2作為增強放射增敏治療活體內放射抗性口腔鱗狀細胞癌的策略

共同主持人

2019/08~

2020/07

大林慈濟醫院
洪世凱

IRAK2與caspase-8的表達在口腔鱗狀細胞癌治療結果及預後的關聯性

主持人

2019/02~

2020/01

大林慈濟醫院
洪世凱

使用體表偵測技術比較正念介入或心理衛教對於接受呼吸調控放射線治療之病人在放射線治療中位移之差異--一個隨機分配臨床試驗

主持人

2018/08-2019/07

大林慈濟醫院
洪世凱

深度發展多面向智能化放射治療安全管控系統

主持人

2018/01-2020/12

佛教慈濟醫療財團法人

洪世凱

膀胱輸尿管逆流以及非生殖泌尿系統相關感染疾病和 INF-r(+874)細胞因子基因之多型性變異的關聯

主持人

2017/08~

2018/07

大林慈濟醫院
洪世凱

比較肝動脈化學栓塞療法後未達完全緩解時合併立體定位燒灼性放射治療或繼續肝動脈化學栓塞療法的觀察性試驗

主持人

2016/07~

2020/06

慈濟醫療志業任務導向之跨院校合作研究計畫

洪世凱

尿道逆流病童的尿蛋白分析及基因之多型性變異的關聯

主持人

2017/02~

2018/01

大林慈濟醫院
洪世凱 109年醫院癌症防治品質精進計畫

協同主持人

2020/01~

2020/12

衛生福利部國民健康署

洪世凱

108年醫院癌症防治品質精進計畫

協同主持人

2019/01~

2019/12

衛生福利部國民健康署

洪世凱

107年醫院癌症防治品質精進計畫

協同主持人

2018/01~

2018/12

衛生福利部國民健康署

 

洪世凱主任學術論文發表

  1. Yu CC, Lin HY, Hsieh CH, Michael WY Chan, Chiou WY,Lee MS, Chi CL, Lin RI, Hsu FC, Chen LC , Chew CH, Yang HJ, Hung SK*. IRAK2, an Immune and Radiation-Response Gene, Correlates with Advanced Disease Features but Predicts Higher Post-Irradiation Local Control in Non-Metastatic and Resected Oral Cancer Patients. International Journal of Molecular Sciences. 2023, 24, 6903.
  2. Chew CH, Lee MS, Chen JC, Wu TH, Chiou WY, Lin HY, Chen LC, Yeh PH, Hung SK*.Outcome of reduced-dose stereotactic radiosurgery for patients with vestibular schwannoma. Ther Radiol Oncol 2022;6:10.
  3. Chuang CJ, Chiou WY, Yang HJ, Lin HY, Hung SK, Lee MS, Chew CH, Yu BH, HsuFC, Chen LC. Impact of preeclampsia/eclampsia on hemorrhagic and ischemic strokerisk: A 17 years follow-up nationwide cohort study. PLoS One. 2022 Nov 9;17(11):e0276206.
  4. Chew CH, Chen JC, Hung SK, Wu TH, Lee MS, Chiou WY, Chen LC, Lin HY. Clinicaloutcomes of benign brain tumors treated with single fraction LINAC-basedstereotactic radiosurgery: Experience of a single institute. Tzu Chi Med J. 2022 Jun 27;34(4):462-472.
  5. Hung SK,Lee MS, Lin HY, Chen LC, Chuang CJ, Chew CH, Yu BH, Yang HJ, Hsu FC,Chiou WY. Impact of Hypertensive Disorders of Pregnancy on the Risk of Stroke Stratified by Subtypes and Follow-Up Time. Stroke. 2022 Feb;53(2):338-344.
  6. Chen YC, Chen HT, Yeh CC, Hung SK, Yu BH. Four prescribed Chinese herbalmedicines provide renoprotection and survival benefit without hyperkalemia riskin patients with advanced chronic kidney disease: A nationwide cohort study.  2022 Jan;95:153873.
  7. Chen LC, Lin HY, Lee MS, Chiou WY, Huang LW, Chew CH, Hsu FC, Hung SK*.Effectiveness of individual audio-visual coaching, respiratory modulatedstereotactic body radiotherapy for localized hepatocellular carcinoma: Analysis of 29 cases from a single academic radiotherapy center. Tzu Chi Med J. 2021 Apr 26;33(4):380-387.
  8. Li HH, Livneh H, Chen WJ, Lu MC, Chiou WY, Hung SK, Yeh CC, Tsai TY. ChineseHerbal Medicine to Reduce Radiation-Induced Oral Mucositis in Head and NeckCancer Patients: Evidence From Population-Based Health Claims. Integr Cancer  2021 Jan-Dec;20:15347354211044833.
  9. Chen LC, Lin HY, Hung SK, Chiou WY, Lee MS. Role of modern radiotherapy inmanaging patients with hepatocellular carcinoma. World J Gastroenterol. 2021 May28;27(20):2434-2457.
  10. Yu CC, Chan MWY, Lin HY, Chiou WY, Lin RI, Chen CA, Lee MS, Chi CL, Chen LC,Huang LW, Chew CH, Hsu FC, Yang HJ, Hung SK*. IRAK2, an IL1R/TLR Immune Mediator, Enhances Radiosensitivity via Modulating Caspase 8/3-Mediated Apoptosis in Oral Squamous Cell Carcinoma. Front Oncol. 2021 Jun 23;11:647175.
  11. Li CY, Chen LC, Lin HY, Lee MS, Hung SK, Lai CL, Huang LW, Yu BH, Hsu FC,Chiou WY. Impact of 23-valent pneumococcal polysaccharide vaccination on thefrequency of pneumonia-related hospitalization and survival in elderly patients with prostate cancer: A seven-year nationwide matched cohort study. Cancer. 2020 Jan 1;127(1):124-136.
  12. Huang LW,Lin HY, Lee MS,Chiou WY, Chen LC, Hung SK*. Clinical-dosimetric Parameters Predicting Non-classic Radiation-induced Liver Disease in Hepatocellular Carcinoma Patients with Barcelona Clinic Liver Cancer (BCLC) Stage A-B: a Retrospective Study. Ther Radiol Oncol. 2020/9. doi: 121037/tro-20-15
  13. Lee MS, Liu DW, Hung SK, Yu CC, Chi CL, Chiou WY, Chen LC, Lin RI, Huang LW,Chew CH, Hsu FC, Chan MWY, Lin HY. Emerging Challenges of Radiation-AssociatedCardiovascular Dysfunction (RACVD) in Modern Radiation Oncology: Clinical Practice, Bench Investigation, and Multidisciplinary Care. Front Cardiovasc Med. 2020 Feb 21;7:16.
  14. Huang LW、Lin HY、Lee MS、Chiou WY、Chen LC、Hung SK*. Combined stereotactic body radiotherapy with conventionally fractionated radiotherapy successfully managing a locoregionally advanced lung cancer patient: a case report. Therapeut Radiol Oncol. 2020;4:3 |http://dx.doi.org/10.21037/2019.11.03
  15. Chen CY、Yeh PH、Chen LC、Chiou WY、Lee MS、Lin HY、Hung SK*.Constructing An online Information System for Infectious Disease: Increasing both Patient and Healthcare Worker Safety During Radiotherapy. Journal of Cancer Studies and Therapeutics [JCST]. Volume 2020 Issue 01
  16. Huang LW、Lin HY、Lee MS、Chiou WY、Chen LC、Hung SK*. Radiotherapy with combined techniques of volumetric-modulated arc therapy (VMAT) and simultaneously intra-tumor inner escalated boost (SIEB) successfully managing a patient with locoregionally advanced maxillary sinus cancer: a case report Ther Radiol Oncol 2020;4:11 | http://dx.doi.org/10.21037/tro-19-46
  17. Chiou WY, Hung SK, Lin HY, Chen LC, Hsu FC, Tsai SJ, Yu BH, Lee MS, Li CY. Effectiveness of 23-valent pneumococcal polysaccharide vaccine on elderly patients with colorectal cancer: A population-based propensity score-matched cohort study. Medicine (Baltimore). 2019 Dec;98(50):e18380.
  18. Chen LC, Chiou WY, Lin HY, Lee MS, Lo YC, Huang LW, Chang CM, Hung TH, Lin CW, Tseng KC, Liu DW, Hsu FC, Hung SK. Comparing stereotactic ablative radiotherapy (SABR) versus re-trans-catheter arterial chemoembolization (re-TACE) for hepatocellular carcinoma patients who had incomplete response after initial TACE (TASABR): a randomized controlled trial. BMC Cancer. 2019 Mar 28;19(1):275.
  19. Liao HF, Lin YZ, Yu CC, Tai TS, Hung SK,Yang CC, Su YC. mTORC1/2 inhibitor served as a more ideal agent against the growth of mouse lymphocytic leukemia both in vitro and in vivo Anticancer Res. 2019Sep;39(9):4829-4835..
  20. Tai TS, Lin PM, Wu CF, Hung SK,Huang CI, Wang CC, Su YC. CDK4/6 InhibitorLEE011 Is a Potential Radiation-sensitizer in Head and Neck Squamous Cell Carcinoma: An <i>In Vitro</i> Study. Anticancer Res. 2019 Feb;39(2):713-720. 
  21. Yu CC, Chen CA, Fu SL, Lin HY, Lee MS, Chiou WY, Su YC, Hung SK. Andrographolide enhances the anti-metastatic effect of radiation in Ras-transformed cells via suppression of ERK-mediated MMP-2 activity. PLoS One. 2018 Oct 25;13(10):e0205666.
  22. Lo YC, Hsu FC, Hung SK, Tseng KC, Hsieh YH, Lee MS,Tseng CW,Lin HY, Chen LC, Chiou WY*. Prognosticators of hepatocellular carcinoma with intrahepatic vascular invasion. Tzu Chi Medical Journal. 2018; DOI:10.4103/tcmj.tcmj_14_18.
  23. Hsu FC, Hung SK, Lin HY, Lee MS, Chiou WY, Lo YC, Chen LC, Tsai WT, Lin YH, Yeh PH, Shih YT. 卓越中心-佛教慈濟醫療財團法人大林慈濟醫院放射腫瘤科放射治療-E手掌握:病人安全-滴水不漏. Journal of Healthcare Quality. 2018 January. 12(1): 16-22.
  24. Yu CC, Hung SK, Lin HY, Chiou WY, Lee MS, Liao HF, Huang HB, Ho HC and Su YC * Targeting the PI3K/AKT/mTOR signaling pathway as an effectively radiosensitizing strategy for treating human oral squamous cell carcinoma in vitro and in vivo. Oncotarget. August 02, 2017
  25. Hsu FC, Hung SK, Lin HY, Lee MS, Chiou WY, Lo YC, Shih YT, Chen CY, Yeh PH, Lin PH. Improving the quality of physiological monitoring during radiotherapy. Chinese health quality management. 2017, 24(Z1); 76-82.
  26. Lin YH, Hung SK, Lee MS, Chiou WY, Lai CL, Shih YT, Yeh PH, Lin YA, Tsai WT, Hsieh HL, Chen LC, Huang LW, Lin PH, Liu DW, Hsu FC, Tsai SJ, Liu JC, Chung ES, Lin HY. Enhancing clinical effectiveness of pre-radiotherapy workflow by using multidisciplinary-cooperating e-control and e-alerts: A SQUIRE-compliant quality-improving study. Medicine (Baltimore). 2017 Jun;96(24):e7185.
  27. Hung SK, Chen YC, Chiou WY, Lai CL,Lee MS, Lo YC, Chen LC, Huang LW,Chien NC, Li SC, Liu DW, Hsu FC, Tsai SJ, Michael WY Chan, Lin HY* Irradiation enhanced risks of hospitalised pneumonopathy in lung cancer patients: a population-based surgical cohort study. BMJ Open.  2017;0:e015022
  28. Chiou WY, Chen CA, Lee MS, Lin HY, Li CY, Su YC, Tsai SJ, Hung SK. Pelvic inflammatory disease increases the risk of a second primary malignancy in patients with cervical cancer treated by surgery alone. Medicine (Baltimore). 2016 Nov;95(47):e5409.
  29. Chen LC, HungSK, Lee MS, ChiouWY, Shen BJ, Shih YT, Hsu FC, Tsai WT, Lin YA, Hsieh HL, Lin PH, Kuo HY, Lin Oral Cancer Patient with an Unresectable Lung Oligometastasis Successfully Treated by Stereotactic Ablative Radiotherapy (SABR) with Simultaneously Integrated Inner-escalated Boost (SIEB): a case report. Therapeut Radiol Oncol. 2016; 23(3): 191-203
  30. Chen LC, HungSK, Lee MS, ChiouWY, Shen BJ, Tsai WT, Lin YA, Hsieh HL, Lin PH, Kuo HY, Lin The essential role of total neuro-axis survey in a medulloblastoma patient with postoperative quadriplegia: a case report. Therapeut Radiol Oncol. 2016; 23(2): 137-143.
  31. Yeh PH, Hung SK, Lee MS, Chiou WY, Lai CL, Tsai WT, Hsieh HL, Shih YT, Chen LC, Huang LW, Y Lin YA, Lin PH, Lin YH, Liu DW, Hsu FC, Tsai SJ, Liu JC, Chung ES, Lin HY. Implementing web-based ping-pong-type e-communication to enhance staff satisfaction, multidisciplinary cooperation, and clinical effectiveness. Medicine.Accepted Oct. 2016(SCI)
  32. Hsu FC, Hung SK, Lee MS, Chiou WY, Shen BJ. Shih YT, Lin YR, Lin YH, Lin HY. Creating a Patient-friendly Medical Environment by Using Regular Patient Satisfaction Survey and PDCA Cycles. Journal of Healthcare Quality. Accepted 13 Jun. 2016
  33. Chiang WH, Tsai1 WT, Lin YH, Lee MS, Lin HY, Chiou HY, Chen LC, Hung SK.Results and benefit analysis of daily quality assurance for a two dimensional image-guided system in Radiotherapy. Therapeut Radiol Oncol. 2016; 23(3): 183-190.
  34. LinYH,Hung SK, Chiou WY, Lee MS, Shen BJ, Chen LC, Liu DW, Tsai WT, Lin PH, Shih YT, Hsu FC, Tsai SJ, Chan MWY, Lin HY. Significant symptoms alleviation and tumor volume reduction after combined simultaneously integrated inner-escalated boost and volumetric-modulated arc radiotherapy in a patient with unresectable bulky hepatocellular carcinoma. A care-compliant case report. Medicine. Accepted  2016. (SCI)
  35. WeiKC,Lin HY, Hung SK, Huang YT, Lee MS, Wang WH, Wu CS, Su YC, Shen BJ, Tsai SJ, Tsai WT, Chen Li CY, Chiou WY. Leukemia Risk After Cardiac Fluoroscopic Interventions Stratified by Procedure Number, Exposure Latent Time, and Sex. A Nationwide Population-Based Case-Control Study. Medicine. 2016 Mar. 95(10): 95(10):e2953 (SCI)
  36. Fu SL, Chen CA, Hung LC,Lee MS, Chiou WY, Lin HY, Su YC, Lee CC,Hung SK. Preliminary results of a non-invasive method to measure tumor size and distribution in vivo. Experimental and Therapeutic medicine. 2016. Oct. 12; 3614-3620. (SCI)
  37. ChiouWY, ChenCA, Lee MS, Lin HY, Li CY, Su YC, Tsai SJ, Hung SK. Pelvic inflammatory disease increases the risk of a second primary malignancy in patients with cervical cancer treated by surgery alone. Medicine. 2016 Nov;95(47):e5409. (SCI)
  38. Hsing CH, Hung SK, Chen YC, Wei TS, Sun DP, Wang JJ, Yeh CH. Histone Deacetylase Inhibitor Trichostatin A Ameliorated Endotoxin-Induced Neuroinflammation and Cognitive Dysfunction. Mediators Inflamm.2015:163140.
  39. Chen YC, Su YC, Li CY, Hung SK. 13-year nationwide cohort study of chronickidney disease risk among treatment-naïve patients with chronic hepatitis B in BMC Nephrol. 2015 Jul. 22; 16:110.
  40. Lee CC, Ho HC, Su YC, Lee MS, Hung SK, Chen YL. The Prognostic Ability of Log Odds of Positive Lymph Nodes in Oral Cavity Squamous Cell Carcinoma. Medicine(Baltimore).2015 Jul. 94(27):e1069.
  41. Chiou WY, Hung SK, Lai CL, Lin HY, Su YC, Chen YC, Shen BJ, Chen LC, Tsai SJ, Lee MS, Li CY. Effect of 23-Valent Pneumococcal Polysaccharide Vaccine InoculatedDuring Anti-Cancer Treatment Period in Elderly Lung Cancer Patients onCommunity-Acquired Pneumonia Hospitalization: A Nationwide Population-Based Cohort Study. Medicine (Baltimore). 2015 Jul. 94(26):e1022. (SCI)
  42. Lee CC, Ho HC, Su YC, Lee MS, Hung SK, Lin CH. MCP1-InducedEpithelial-Mesenchymal Transition in Head and Neck Cancer by AKT Activation.Anticancer Res. 2015 Jun. 35(6):3299-306.
  43. Hsieh CH, Wei CK, Yin WY, Chang CM, Tsai SJ, Wang LY, Chiou WY, Lee MS, LinHY, Hung SK. Vascular invasion affects survival in early hepatocellular Mol Clin Oncol. 2015 Jan. 3(1):252-256.
  44. Lin HY, Hung SK, Lee MS, Chiou WY, Huang TT, Tseng CE, Shih LY, Lin RI, LinJM, Lai YH, Chang CB, Hsu FC, Chen LC, Tsai SJ, Su YC, Li SC, Lai HC, Hsu WL, LiuDW, Tai CK, Wu SF, Chan MW. DNA methylome analysis identifies epigenetic silencing of FHIT as a determining factor for radiosensitivity in oral cancer: an outcome-predicting and treatment-implicating study. Oncotarget. 2015 Jan. 20;6(2):915-34. (SCI)
  45. Tsai SJ, Ruan YX, Lee CC, Lee MS, Chiou WY, Lin HY, Hsu FC, Su YC, Hsu TW,Hung SK. Use of Chinese medicine among colorectal cancer patients: a nationwidepopulation-based study. Afr J Tradit Complement Altern Med. 2014 Jan.28;11(2):343-9.
  46. Chiou WY, Chang CM, Tseng KC, Hung SK, Lin HY, Chen YC, Su YC, Tseng CW, Tsai SJ, Lee MS, Li CY. Effect of liver cirrhosis on metastasis in colorectal cancerpatients: a nationwide population-based cohort study. Jpn J Clin Oncol.2015 Feb. 45(2):160-8.
  47. Lee MS, Tsai SJ, Lee CC, Su YC, Chiou WY, Lin HY, Hung SK. Higher caseloadimproves cervical cancer survival in patients treated with brachytherapy. Radiat 2014 Oct. 25;9:234.
  48. Su YC, Yu CC, Hsu FT, Fu SL, Hwang JJ, Hung LC, Lee MS, Chiou WY, Lin HY,Hung SK. Everolimus sensitizes Ras-transformed cells to radiation in vitrothrough the autophagy pathway. Int J Mol Med. 2014 Nov. 34(5):1417-22.
  49. Chen YL, Wang CY, Wu CC, Lee MS, Hung SK, Chen WC, Hsu CY, Hsu CW, Huang CY, Su YC, Lee CC. Prognostic influences of lymph node ratio in major cancers ofTaiwan: a longitudinal study from a single cancer center. J Cancer Res Clin 2015 Feb. 141(2):333-43.
  50. Yu CC, Hung SK, Liao HF, Lee CC, Lin HY, Lai HC, Li SC, Ho HC, Huang HB, Su RAD001 enhances the radiosensitivity of SCC4 oral cancer cells by inducingcell cycle arrest at the G2/M checkpoint. Anticancer Res. 2014 Jun. 34(6):2927-35.
  51. Hung SK, Lee MS, Chiou WY, Lee CC, Chen YC, Lai CL, Chien NC, Hsu WL, Liu DW,Su YC, Li SC, Lai HC, Tsai SJ, Hsu FC, Lin HY. High incidence of ischemic stroke occurrence in irradiated lung cancer patients: a population-based surgical cohort PLoS One. 2014 Apr. 7;9(4):e94377.
  52. Liu SH, Lin CH, Liang FP, Chen PF, Kuo CD, Alam MM, Maiti B, Hung SK, Chi CW,Sun CM, Fu SL. Andrographolide downregulates the v-Src and Bcr-Abl oncoproteinsand induces Hsp90 cleavage in the ROS-dependent suppression of cancer malignancy. Biochem Pharmacol. 2014 Jan. 15;87(2):229-42.
  53. Lee CC, Ho HC, Chien SH, Hsiao SH, Hung SK, Huang TT, Yu CC, Chang SM, Huang HH, Su YC. Association of acute phase protein-haptoglobin, andepithelial-mesenchymal transition in buccal cancer: a preliminary report. ClinChem Lab Med. 2013 Feb. 51(2):429-37.
  54. Hsieh CH, Tsai SJ, Chiou WY, Lee MS, Lin HY, Hung SK. Better survival with three-dimensional conformal radiotherapy than with conventional radiotherapy for cervical cancer: a population-based study. ISRN Oncol. 2013 Oct.2;2013
  55. Hsieh CH, Chiou WY, Lee CC, Lee MS, Lin HY, Su YC, Hung SK. Factors affecting myocardial infarction in cervical cancer patients: a population-based study. J Clin Med Res.2013 Dec.5(6):467-74.
  56. Liu SH, Lin CH, Liang FP, Chen PF, Kuo CD, Alam MM, Maiti B, Hung SK, Chi CW, Sun CM, Fu SL. Andrographolide downregulates the v-Src and Bcr-Abl oncoproteins and induces Hsp90 cleavage in the ROS-dependent suppression of cancer malignancy. Biochem Pharmacol. 2014 Jan. 15;87(2):229-42. (SCI)
  57. Chen YC, Chiou WY, Hung SK, Su YC, Hwang SJ. Hepatitis C virus itself is a causal risk factor for chronic kidney disease beyond traditional risk factors: a 6-year nationwide cohort study across Taiwan. BMC Nephrol2013 Sep.. 6;14:187. (SCI)
  58. Hsu TW, Lu HJ, Wei CK, Yin WY, Chang CM, Chiou WY, Lee MS, Lin HY, Su YC, Hung SK. Clinical and pathologic factors affecting lymph node yields in colorectal cancer. PLoS One. 2013 Jul.16;8(7):e68526. (SCI)
  59. Chen LF, Ho HC, Su YC, Lee MS, Hung SK, Chou P, Lee CC, Lin LC, Lee CC. Association between provider volume and healthcare expenditures of patients with oral cancer in Taiwan: a population-based study. PLoS One. 2013 Jun.4;8(6):e65077. (SCI)
  60. Chuang TL, Wang YF, Tsai CH, Chiu JE, Lee MS, Chiou WY,Lin HY, Tsai WT, Hung SK.Evaluation of salivary function by sialoscintigraphy in locally advanced nasopharyngeal cancer patients after intensity modulated radiotherapy. Indian J Cancer. (SCI) (In Press)
  61. Shih YT,Lee MS, Lin HY,Chiou WY, Chen FL, Tsai WT, Lin PH, Lu MC, Lin YH, Chang CC, Hsu FC, Hung SK. Using a wireless emergent ringer during daily radiotherapy increasing patient -reported confidence of treatment safety. Healthcare Qual. 第五卷第一期/18-33
  62. Chiou WY, Lee MS, Ho HC, Hung SK, Lin HY, Su YC, Lee CC. Prognosticators and the relationship of depressionand quality of life in head and neck cancer.Indian J Cancer. (SCI) (In Press)
  63. Lee CC, Ho HC, Chien SH,Hsiao, SH, Hung SK, Huang TT, Yu CC, Chang SM, Huang HH, Su YC. Association of acute phase protein-haptoglobin and epithelial mesenchymal transition in buccal cancer: a preliminary report.Clin Chem Lab Med. (SCI) (In Press)
  64. Lin HY,HuangTT, Lee MS, Hung SK, Lin RI , Tseng CE, Chang SM, Chiou WY, Hsu FC, Hsu WL, Liu DW, Su YC, Li SC, Chan MW. Unexpected close surgical margin in resected buccal cancer: Very close margin and DAPK promoter hypermethylation predict poor clinical outcomes. 2013. Oral Oncol. 49(4):336-44. (SCI)
  65. Lee CC,Su YC, Chien SH, Ho HC, Hung SK, Lee MS, Chou P, Chiu BC, Huang YS. Increased stroke risk in Bell’s palsy patients without steroid treatment.Eur J Neurol. 2013. 20(4):616-22. (SCI)
  66. Tsai SJ, Huang YU, Tung CH, Lee CC, Lee MS, Chiou WY,Lin HY,Hsu FC, Su YC, Hung SK. Increased risk of ischemic stroke in cervical cancer patients: a nationwide population-based study. Radiat Oncol. 8:41. (SCI)
  67. Hsu TW, Wei CK, Yin WY, Chang CM, Chiou WY, Lee MS, Lin HY,Su YC,Lu HJ, Hung SK. Prognostic factors impacting short-term outcome of curative rectal cancer resection. Tzu Chi Med J.  2013. 25(1):47-50.

余芝嘉助理研究員學術論文發表

  1. Chih-Chia Yu, Hon-Yi Lin, Chen-Hsi Hsieh, Michael W. Y. Chan, Wen-Yen Chiou,Moon-Sing Lee, Chen-Lin Chi, Ru-Inn Lin, Feng-Chun Hsu, Liang-Cheng Chen, Chia-Hui Chew,Hsuan-Ju Yang and Shih-Kai Hung. IRAK2, an Immune and Radiation-Response Gene, Correlates with Advanced Disease Features but Predicts Higher Post-Irradiation Local Control in Non-Metastatic and Resected Oral Cancer Patients. International Journal of Molecular Sciences 2023, 24(8), 6903.  
  2. Chih-Chia Yu, Michael W.Y. Chan, Hon-Yi Lin, Wen-Yen Chiou, Ru-Inn Lin, Chien-An Chen, Moon-Sing Lee, Chen-Lin Chi, Liang-Cheng Chen, Li-Wen Huang, Chia-Hui Chew, Feng-Chun Hsu, Hsuan-Ju Yang and Shih-Kai Hung. IRAK2, an IL1R/TLR Immune Mediator, Enhances Radiosensitivity via Modulating Caspase 8/3-Mediated Apoptosis in Oral Squamous Cell Carcinoma. Frontiers in Oncology 2021,6:11.
  3. Moon-Sing Lee, Dai-Wei Liu, Shih-Kai Hung, Chih-Chia Yu, Chen-Lin Chi, Wen-Yen Chiou, Liang-Cheng Chen, Ru-Inn Lin, Li-Wen Huang, Chia-Hui Chew, Feng-Chun Hsu, Michael W. Y. Chan and Hon-Yi Lin. Emerging challenges of radiation-associated cardiovascular dysfunction (RACVD) in modern radiation oncology: clinical practice, bench investigation, and multidisciplinary care. Frontiers in Cardiovascular Medicine 2020, 7:16.
  4. Pie-Che Chen, Chih-Chia Yu*, Wen-Yu Huang, Wan-Hong Huang, Yu-Ming Chuang, Ru-Inn Lin, Jora M. J. Lin, Hon-Yi Lin, Yeong-Chin Jou, Cheng-Huang Shen and Michael W. Y. Chan. c-Myc acts as a competing endogenous RNA to sponge miR-34a, in the upregulation of CD44, in urothelial carcinoma. cancers 2019, 11, 1457.
  5. Liao HF, Lin YZ, Yu CC, Tai TS, Hung SK, Yang CC, Su YC. mTORC1/2 inhibitor served as a more ideal agent against the growth of mouse lymphocytic leukemia both in vitro and in vivo. Anticancer Res. 2019 Sep;39(9):4829-4835.
  6. Yu CC, Chen CA, Fu SL, Lin HY, Lee MS, Chiou WY, Su YC, Hung SK. Andrographolideenhancesthe anti-metastatic effect of radiation in Ras-transformed cells via suppression of ERK-mediated MMP-2 activity. PLoS One. 2018 Oct 25;13(10):e0205666.
  7. Yu CC, Hung SK, Lin HY, Chiou WY, Lee MS, Liao HF, Huang HB, Ho HC, Su YC. Targeting the PI3K/AKT/mTOR signaling pathway as an effectively radiosensitizing strategy for treating human oral squamous cell carcinoma in vitroand in vivo. 2017 Aug 2;8(40):68641-68653.
  8. Yu CC, Huang HB, Hung SK, Liao HF, Lee CC, Lin HY, Li SC, Ho HC, Hung CL, Su YC. AZD2014 Radiosensitizes Oral Squamous Cell Carcinoma by Inhibiting AKT/mTOR Axis and Inducing G1/G2/M Cell Cycle Arrest.PLoS One. 2016 Mar 31;11(3):e0151942.
  9. Su YC, Yu CC*, Hsu FT, Fu SL, Hwang JJ, Hung LC, Lee MS, Chiou WY, Lin HY, Hung SK. Everolimus sensitizes Ras-transformed cells to radiation in vitro through the autophagy pathway.Int J Mol Med. 2014 Nov;34(5):1417-22.
  10. Yu CC, Hung SK, Liao HF, Lee CC, Lin HY, Lai HC, Li SC, Ho HC, Huang HB, Su YC. RAD001 enhances the radiosensitivity of SCC4 oral cancer cells by inducing cell cycle arrest at the G2/M checkpoint.Anticancer Res. 2014 Jun;34(6):2927-35.
  11. Lee CC, Ho HC, Chien SH, Hsiao SH, Hung SK, Huang TT, Yu CC, Chang SM, Huang HH, Su YC. Association of acute phase protein-haptoglobin, and epithelial-mesenchymal transition in buccal cancer: a preliminary report.Clin Chem Lab Med. 2013 Feb;51(2):429-37.
  12. Chen YC, Lee CC, Huang CY, Huang HB, Yu CC, Ho YC, Su YC. Haptoglobin polymorphism as a risk factor for chronic kidney disease: a case-control study.Am J Nephrol. 2011;33(6):510-4.
  13. Haptoglobin Genotypes Correlate with the Survival of Patients with Colorectal Cancer=回溯性探討Haptoglobin Genotype與非轉移之大腸癌之存活情形之關聯性 賴泓誌 ; 陳宜鈞 ; 魏昌國 ; 林宏益 ; 余芝嘉; 李思錦 ; 洪世凱 ; 周明智 ; 蘇裕傑 臺灣癌症醫學雜誌 28:2 2012.06[民06] 頁68-75.
  14. Yu-Jen Chen; Yu-Yawn Chen; Chia-Tien Wu; Chih-Chia Yu; Hui-Fen Liao. Prolamin, a rice protein, augments anti-leukaemia immune response. Journal of Cereal Science. 2010 March. 51 (2): 189-197.
  15. Lee CC, Ho HC, Lee MS, Hung SK, Yu CC, Su YC. Expression of haptoglobin predicts recurrence in head and neck squamous cell carcinoma.Clin Chim Acta. 2010 Aug 5;411(15-16):1116-21.
  16. Yu-Jen Chen,Chih-Chia Yu*, Shui-Tein Chen,Tai-Yuan Chen and Hui-Fen Liao. Functional regulation and proteomic characterization of human natural killer cells through recombinant human granulocyte-colony stimulating factor Proteomics Clinical Applications. 2009 May, 3(5): 563-573. 
  17. Haptoglobin Polymorphism in Breast Cancer=Haptoglobin基因多型性與乳癌之關係 李思錦 ; 陳宜鈞 ; 魏昌國 ; 林俊宏 ; 余芝嘉; 董雅庭 ; 蘇裕傑 中華民國癌症醫學會雜誌 25:3 2009.06[民06] 頁175-183.
  18. Chen YJ, Kuo CD, Tsai YM, Yu CC, Wang GS, Liao HF. Norcantharidin induces anoikis through Jun-N-terminal kinase activation in CT26 colorectal cancer cells.Anticancer Drugs. 2008 Jan;19(1):55-64.
  19. Lin CY, Tsui KH, Yu CC, Yeh CW, Chang PL, Yung BY. Searching cell-secreted proteomes for potential urinary bladder tumor markers. 2006 Aug;6(15):4381-9.